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Lineage for d5muta_ (5mut A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2080000Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families) (S)
  5. 2080001Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 protein domains)
  6. 2080046Protein Dihydroorotate dehydrogenase [51397] (8 species)
  7. 2080052Species Human (Homo sapiens) [TaxId:9606] [51400] (42 PDB entries)
  8. 2287507Domain d5muta_: 5mut A: [330808]
    automated match to d3kvma_
    complexed with act, cl, fmn, hyt, oro

Details for d5muta_

PDB Entry: 5mut (more details), 1.75 Å

PDB Description: crystal structure of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds
PDB Compounds: (A:) Dihydroorotate dehydrogenase (quinone), mitochondrial

SCOPe Domain Sequences for d5muta_:

Sequence, based on SEQRES records: (download)

>d5muta_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
tgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnp
vgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfns
hglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvv
nvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasv
vkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpii
gvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaig
adhrr

Sequence, based on observed residues (ATOM records): (download)

>d5muta_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
tgderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpvgi
aagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgl
svvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvg
kaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtntt
vsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdaleki
ragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr

SCOPe Domain Coordinates for d5muta_:

Click to download the PDB-style file with coordinates for d5muta_.
(The format of our PDB-style files is described here.)

Timeline for d5muta_:

  • d5muta_ appears in periodic updates to SCOPe 2.06 starting on 2017-03-09