Lineage for d5mvda_ (5mvd A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2080000Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families) (S)
  5. 2080001Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 protein domains)
  6. 2080046Protein Dihydroorotate dehydrogenase [51397] (8 species)
  7. 2080052Species Human (Homo sapiens) [TaxId:9606] [51400] (43 PDB entries)
  8. 2287439Domain d5mvda_: 5mvd A: [330740]
    automated match to d2fpva_
    complexed with act, cl, fmn, oro, u91

Details for d5mvda_

PDB Entry: 5mvd (more details), 1.95 Å

PDB Description: crystal structure of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds
PDB Compounds: (A:) Dihydroorotate dehydrogenase (quinone), mitochondrial

SCOPe Domain Sequences for d5mvda_:

Sequence, based on SEQRES records: (download)

>d5mvda_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
derfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpvg
iaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshg
lsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnv
sspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvk
elgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigv
ggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigad
hrr

Sequence, based on observed residues (ATOM records): (download)

>d5mvda_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
derfyaehlmptlqglldpesahrlavrftslgllpdsdmlevrvlghkfrnpvgiaagf
dkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshglsvve
hrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvsspka
elrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtnttvs
rpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdalekira
gaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr

SCOPe Domain Coordinates for d5mvda_:

Click to download the PDB-style file with coordinates for d5mvda_.
(The format of our PDB-style files is described here.)

Timeline for d5mvda_:

  • d5mvda_ appears in periodic updates to SCOPe 2.06 starting on 2017-03-08