SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5tkua_ (5tku A:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2055629Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2055630Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2058159Family b.47.1.0: automated matches [191364] (1 protein)
    not a true family
  6. 2058160Protein automated matches [190438] (24 species)
    not a true protein
  7. 2058190Species Human (Homo sapiens) [TaxId:9606] [187421] (60 PDB entries)
  8. 2287214Domain d5tkua_: 5tku A: [330515]
    automated match to d1p57b_
    complexed with 7dk, edo, so4

Details for d5tkua_

PDB Entry: 5tku (more details), 2.12 Å

PDB Description: factor xia in complex with the inhibitor methyl ((15s)-15-(((2e)-3-(5- chloro-2-(1h-tetrazol-1-yl)phenyl)-2-propenoyl)amino)-9-oxo-8,17,19- triazatricyclo[,7~]nonadeca-1(18),2,4,6,16(19)-pentaen-5- yl)carbamate
PDB Compounds: (A:) Factor XIa (Light Chain)

SCOPe Domain Sequences for d5tkua_:

Sequence; same for both SEQRES and ATOM records: (download)

>d5tkua_ b.47.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d5tkua_:

Click to download the PDB-style file with coordinates for d5tkua_.
(The format of our PDB-style files is described here.)

Timeline for d5tkua_:

  • d5tkua_ appears in periodic updates to SCOPe 2.06 starting on 2017-03-02