SCOPe 2.08: Domain d5m4ka1: 5m4k A:6-169

Lineage for d5m4ka1 (5m4k A:6-169)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.5: alpha-ketoacid dehydrogenase kinase, N-terminal domain [69012] (2 families)
   automatically mapped to Pfam PF10436

5. Family a.29.5.1: alpha-ketoacid dehydrogenase kinase, N-terminal domain [69013] (3 proteins)

6. Protein automated matches [230549] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [230552] (22 PDB entries)

8. Domain d5m4ka1: 5m4k A:6-169 [330294]
   Other proteins in same PDB: d5m4ka2
   automated match to d1y8pa1
   complexed with 7f9, mg, tf3

Details for d5m4ka1

PDB Entry: 5m4k, 2.6 Å

PDB Description: application of off-rate screening in the identification of novel pan- isoform inhibitors of pyruvate dehydrogenase kinase

PDB Compounds: (A:) [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

SCOPe Domain Sequences for d5m4ka1:

Sequence, based on SEQRES records:

>d5m4ka1 a.29.5.1 (A:6-169) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gsapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlanimkeinllpd
rvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptmaqg
vleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifd

Sequence, based on observed residues (ATOM records):

>d5m4ka1 a.29.5.1 (A:6-169) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gsapkyiehfskfspsplsmkqfldfnacektsftflrqelpvrlanimkeinllpdrvl
stpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptmaqgvle
ykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifd

Timeline for d5m4ka1:

• d5m4ka1 first appeared in SCOPe 2.06
  
• d5m4ka1 appears in SCOPe 2.07