SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5tzhd_ (5tzh D:)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2014835Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  4. 2014836Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families) (S)
  5. 2015250Family a.211.1.0: automated matches [191566] (1 protein)
    not a true family
  6. 2015251Protein automated matches [190983] (8 species)
    not a true protein
  7. 2015252Species Human (Homo sapiens) [TaxId:9606] [188676] (102 PDB entries)
  8. 2286960Domain d5tzhd_: 5tzh D: [330261]
    Other proteins in same PDB: d5tzha2, d5tzhb2
    automated match to d4d09a_
    complexed with 7op, mg, zn

Details for d5tzhd_

PDB Entry: 5tzh (more details), 1.6 Å

PDB Description: crystal structure of human phosphodiesterase 2a in complex with 3,3- difluoro-1-[(4-fluorophenyl)carbonyl]-5-{5-methyl-[1,2,4]triazolo[1, 5-a]pyrimidin-7-yl}piperidine
PDB Compounds: (D:) cGMP-dependent 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d5tzhd_:

Sequence; same for both SEQRES and ATOM records: (download)

>d5tzhd_ a.211.1.0 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
iqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidcptlarfclmvkkg
yrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmchdldhrgtnnsfqv
asksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqrmldlmrdiilatd
lahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgwkttrkiaeliyke
ffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqdlfpkaaelyerva
snrehwtkvshkftirglpsnnsldfl

SCOPe Domain Coordinates for d5tzhd_:

Click to download the PDB-style file with coordinates for d5tzhd_.
(The format of our PDB-style files is described here.)

Timeline for d5tzhd_:

  • d5tzhd_ appears in periodic updates to SCOPe 2.06 starting on 2017-02-23