SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5ugxb_ (5ugx B:)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2195690Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 protein domains)
    members organized in the groups and subfamiles specified by the comments
  6. 2198144Protein automated matches [190091] (14 species)
    not a true protein
  7. 2198237Species Human (Homo sapiens) [TaxId:9606] [188447] (583 PDB entries)
  8. 2286924Domain d5ugxb_: 5ugx B: [330225]
    automated match to d4v04b_
    complexed with acp, mg, so4; mutant

Details for d5ugxb_

PDB Entry: 5ugx (more details), 2.35 Å

PDB Description: crystal structure of the tyrosine kinase domain of fgf receptor 2 harboring a e565a/d650v double gain-of-function mutation
PDB Compounds: (B:) Fibroblast growth factor receptor 2

SCOPe Domain Sequences for d5ugxb_:

Sequence, based on SEQRES records: (download)

>d5ugxb_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatekd
lsdlvsememmkmigkhkniinllgactqdgplyvivayaskgnlreylrarrppgmeys
ydinrvpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfgl
arvinnidyykkttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgi
pveelfkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt

Sequence, based on observed residues (ATOM records): (download)

>d5ugxb_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatekd
lsdlvsememmkmigkhkniinllgactqdgplyvivayaskgnlreylrarrppgminr
vpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglarvtn
grlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrm
dkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt

SCOPe Domain Coordinates for d5ugxb_:

Click to download the PDB-style file with coordinates for d5ugxb_.
(The format of our PDB-style files is described here.)

Timeline for d5ugxb_:

  • d5ugxb_ appears in periodic updates to SCOPe 2.06 starting on 2017-02-23