SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5tnbc_ (5tnb C:)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2008476Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
    multihelical; 3 layers or orthogonally packed helices
  4. 2008477Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families) (S)
  5. 2008478Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 protein domains)
  6. 2009403Protein automated matches [190059] (14 species)
    not a true protein
  7. 2009425Species Human (Homo sapiens) [TaxId:9606] [187214] (171 PDB entries)
  8. 2286581Domain d5tnbc_: 5tnb C: [329882]
    automated match to d3q95b_
    complexed with 7eb

Details for d5tnbc_

PDB Entry: 5tnb (more details), 2.08 Å

PDB Description: crystal structure of the er-alpha ligand-binding domain (l372s,l536s) in complex with the obhs-bsc, 4-bromophenyl (1r,2r,4s)-6-(4-(2- (dimethylamino)ethoxy)phenyl)-5-(4-hydroxyphenyl)-7- oxabicyclo[2.2.1]hept-5-ene-2-sulfonate
PDB Compounds: (C:) Estrogen receptor

SCOPe Domain Sequences for d5tnbc_:

Sequence, based on SEQRES records: (download)

>d5tnbc_ a.123.1.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemld
a

Sequence, based on observed residues (ATOM records): (download)

>d5tnbc_ a.123.1.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrngmveifdmllat
ssrfrmmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlihlmaka
gltlqqqhqrlaqlllilshirhmsnkgmehlysmvvpsydlllemlda

SCOPe Domain Coordinates for d5tnbc_:

Click to download the PDB-style file with coordinates for d5tnbc_.
(The format of our PDB-style files is described here.)

Timeline for d5tnbc_:

  • d5tnbc_ appears in periodic updates to SCOPe 2.06 starting on 2017-02-16