SCOPe 2.06: Domain d5grfa_: 5grf A:

Lineage for d5grfa_ (5grf A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.0: automated matches [191423] (1 protein)
   not a true family

6. Protein automated matches [190603] (16 species)
   not a true protein

7. Species Homo sapiens [TaxId:9606] [329721] (5 PDB entries)

8. Domain d5grfa_: 5grf A: [329811]
   automated match to d3blxo_
   complexed with adp, cit, mg; mutant

Details for d5grfa_

PDB Entry: 5grf, 2.5 Å

PDB Description: crystal structure of the alpha gamma mutant (gamma-k151a) of human idh3 in complex with mg(2+), citrate and adp

PDB Compounds: (A:) Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

SCOPe Domain Sequences for d5grfa_:

Sequence, based on SEQRES records:

>d5grfa_ c.77.1.0 (A:) automated matches {Homo sapiens [TaxId: 9606]}
vqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqgpggkwmipseakesmdk
nkmglkgplktpiaaghpsmnlllrktfdlyanvrpcvsiegyktpytdvnivtirente
geysgiehvivdgvvqsiklitegaskriaefafeyarnnhrsnvtavhkanimrmsdgl
flqkcrevaesckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcagliggl
gvtpsgnigangvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaarieaa
cfatikdgksltkdlggnakcsdfteeicrrvkdl

Sequence, based on observed residues (ATOM records):

>d5grfa_ c.77.1.0 (A:) automated matches {Homo sapiens [TaxId: 9606]}
vqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqwmipseakesmdknkmgl
kgplktppsmnlllrktfdlyanvrpcvsiegyktpytdvnivtirentegeysgiehvi
vdgvvqsiklitegaskriaefafeyarnnhrsnvtavhkanimrmsdglflqkcrevae
sckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcagligglgvtpsgniga
ngvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaarieaacfatikdgks
ltkdlgnakcsdfteeicrrvkdl

Timeline for d5grfa_:

• d5grfa_ is new in SCOPe 2.06-stable
  
• d5grfa_ appears in SCOPe 2.07
  
• d5grfa_ appears in the current release, SCOPe 2.08