SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5grfa_ (5grf A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2138632Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2138633Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2138965Family c.77.1.0: automated matches [191423] (1 protein)
    not a true family
  6. 2138966Protein automated matches [190603] (16 species)
    not a true protein
  7. 2286420Species Homo sapiens [TaxId:9606] [329721] (5 PDB entries)
  8. 2286510Domain d5grfa_: 5grf A: [329811]
    automated match to d3blxo_
    complexed with adp, cit, mg; mutant

Details for d5grfa_

PDB Entry: 5grf (more details), 2.5 Å

PDB Description: crystal structure of the alpha gamma mutant (gamma-k151a) of human idh3 in complex with mg(2+), citrate and adp
PDB Compounds: (A:) Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

SCOPe Domain Sequences for d5grfa_:

Sequence, based on SEQRES records: (download)

>d5grfa_ c.77.1.0 (A:) automated matches {Homo sapiens [TaxId: 9606]}
vqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqgpggkwmipseakesmdk
nkmglkgplktpiaaghpsmnlllrktfdlyanvrpcvsiegyktpytdvnivtirente
geysgiehvivdgvvqsiklitegaskriaefafeyarnnhrsnvtavhkanimrmsdgl
flqkcrevaesckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcagliggl
gvtpsgnigangvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaarieaa
cfatikdgksltkdlggnakcsdfteeicrrvkdl

Sequence, based on observed residues (ATOM records): (download)

>d5grfa_ c.77.1.0 (A:) automated matches {Homo sapiens [TaxId: 9606]}
vqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqwmipseakesmdknkmgl
kgplktppsmnlllrktfdlyanvrpcvsiegyktpytdvnivtirentegeysgiehvi
vdgvvqsiklitegaskriaefafeyarnnhrsnvtavhkanimrmsdglflqkcrevae
sckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcagligglgvtpsgniga
ngvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaarieaacfatikdgks
ltkdlgnakcsdfteeicrrvkdl

SCOPe Domain Coordinates for d5grfa_:

Click to download the PDB-style file with coordinates for d5grfa_.
(The format of our PDB-style files is described here.)

Timeline for d5grfa_:

  • d5grfa_ appears in periodic updates to SCOPe 2.06 starting on 2017-02-15