Lineage for d5grfa_ (5grf A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2138632Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2138633Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2138965Family c.77.1.0: automated matches [191423] (1 protein)
    not a true family
  6. 2138966Protein automated matches [190603] (16 species)
    not a true protein
  7. 2286420Species Homo sapiens [TaxId:9606] [329721] (5 PDB entries)
  8. 2286510Domain d5grfa_: 5grf A: [329811]
    automated match to d3blxo_
    complexed with adp, cit, mg; mutant

Details for d5grfa_

PDB Entry: 5grf (more details), 2.5 Å

PDB Description: crystal structure of the alpha gamma mutant (gamma-k151a) of human idh3 in complex with mg(2+), citrate and adp
PDB Compounds: (A:) Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

SCOPe Domain Sequences for d5grfa_:

Sequence, based on SEQRES records: (download)

>d5grfa_ c.77.1.0 (A:) automated matches {Homo sapiens [TaxId: 9606]}
vqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqgpggkwmipseakesmdk
nkmglkgplktpiaaghpsmnlllrktfdlyanvrpcvsiegyktpytdvnivtirente
geysgiehvivdgvvqsiklitegaskriaefafeyarnnhrsnvtavhkanimrmsdgl
flqkcrevaesckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcagliggl
gvtpsgnigangvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaarieaa
cfatikdgksltkdlggnakcsdfteeicrrvkdl

Sequence, based on observed residues (ATOM records): (download)

>d5grfa_ c.77.1.0 (A:) automated matches {Homo sapiens [TaxId: 9606]}
vqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqwmipseakesmdknkmgl
kgplktppsmnlllrktfdlyanvrpcvsiegyktpytdvnivtirentegeysgiehvi
vdgvvqsiklitegaskriaefafeyarnnhrsnvtavhkanimrmsdglflqkcrevae
sckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcagligglgvtpsgniga
ngvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaarieaacfatikdgks
ltkdlgnakcsdfteeicrrvkdl

SCOPe Domain Coordinates for d5grfa_:

Click to download the PDB-style file with coordinates for d5grfa_.
(The format of our PDB-style files is described here.)

Timeline for d5grfa_:

  • d5grfa_ appears in periodic updates to SCOPe 2.06 starting on 2017-02-15