SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5grhb_ (5grh B:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2138632Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2138633Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2138965Family c.77.1.0: automated matches [191423] (1 protein)
    not a true family
  6. 2138966Protein automated matches [190603] (16 species)
    not a true protein
  7. 2286420Species Homo sapiens [TaxId:9606] [329721] (5 PDB entries)
  8. 2286475Domain d5grhb_: 5grh B: [329776]
    automated match to d3blxc_
    complexed with mg

Details for d5grhb_

PDB Entry: 5grh (more details), 2.8 Å

PDB Description: crystal structure of the alpha gamma heterodimer of human idh3 in complex with mg(2+)
PDB Compounds: (B:) Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

SCOPe Domain Sequences for d5grhb_:

Sequence; same for both SEQRES and ATOM records: (download)

>d5grhb_ c.77.1.0 (B:) automated matches {Homo sapiens [TaxId: 9606]}
grhtvtmipgdgigpelmlhvksvfrhacvpvdfeevhvssnadeedirnaimairrnrv
alkgnietnhnlppshksrnnilrtsldlyanvihckslpgvvtrhkdidilivrenteg
eysslehesvagvveslkiitkakslriaeyafklaqesgrkkvtavhkanimklgdglf
lqccrevaarypqitfenmivdnttmqlvsrpqqfdvmvmpnlygnivnnvcaglvggpg
lvaganyghvyavfetatrntgksianknianptatllascmmldhlklhsyatsirkav
lasmdnenmhtpdiggqgttseaiqdvirhirvin

SCOPe Domain Coordinates for d5grhb_:

Click to download the PDB-style file with coordinates for d5grhb_.
(The format of our PDB-style files is described here.)

Timeline for d5grhb_:

  • d5grhb_ appears in periodic updates to SCOPe 2.06 starting on 2017-02-15