SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5grfb_ (5grf B:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2138632Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2138633Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2138965Family c.77.1.0: automated matches [191423] (1 protein)
    not a true family
  6. 2138966Protein automated matches [190603] (16 species)
    not a true protein
  7. 2286420Species Homo sapiens [TaxId:9606] [329721] (5 PDB entries)
  8. 2286428Domain d5grfb_: 5grf B: [329729]
    automated match to d3blxc_
    complexed with adp, cit, mg; mutant

Details for d5grfb_

PDB Entry: 5grf (more details), 2.5 Å

PDB Description: crystal structure of the alpha gamma mutant (gamma-k151a) of human idh3 in complex with mg(2+), citrate and adp
PDB Compounds: (B:) Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

SCOPe Domain Sequences for d5grfb_:

Sequence; same for both SEQRES and ATOM records: (download)

>d5grfb_ c.77.1.0 (B:) automated matches {Homo sapiens [TaxId: 9606]}
rhtvtmipgdgigpelmlhvksvfrhacvpvdfeevhvssnadeedirnaimairrnrva
lkgnietnhnlppshksrnnilrtsldlyanvihckslpgvvtrhkdidilivrentege
ysslehesvagvveslaiitkakslriaeyafklaqesgrkkvtavhkanimklgdglfl
qccrevaarypqitfenmivdnttmqlvsrpqqfdvmvmpnlygnivnnvcaglvggpgl
vaganyghvyavfetatrntgksianknianptatllascmmldhlklhsyatsirkavl
asmdnenmhtpdiggqgttseaiqdvirhirving

SCOPe Domain Coordinates for d5grfb_:

Click to download the PDB-style file with coordinates for d5grfb_.
(The format of our PDB-style files is described here.)

Timeline for d5grfb_:

  • d5grfb_ appears in periodic updates to SCOPe 2.06 starting on 2017-02-15