SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Species: Homo sapiens [TaxId: 9606]

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2138632Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2138633Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2138965Family c.77.1.0: automated matches [191423] (1 protein)
    not a true family
  6. 2138966Protein automated matches [190603] (16 species)
    not a true protein
  7. 2286420Species Homo sapiens [TaxId:9606] [329721] (5 PDB entries)

PDB entries in Species: Homo sapiens [TaxId: 9606]:

  1. Domain(s) for 5gre:
    1. 2286469Domain d5greb_: 5gre B: [329770]
      automated match to d3blxc_
      complexed with adp, cit, mg
    2. 2286496Domain d5grea_: 5gre A: [329797]
      automated match to d3blxo_
      complexed with adp, cit, mg
  2. Domain(s) for 5grf:
    1. 2286428Domain d5grfb_: 5grf B: [329729]
      automated match to d3blxc_
      complexed with adp, cit, mg; mutant
    2. 2286510Domain d5grfa_: 5grf A: [329811]
      automated match to d3blxo_
      complexed with adp, cit, mg; mutant
  3. Domain(s) for 5grh:
    1. 2286421Domain d5grha_: 5grh A: [329722]
      automated match to d3blxo_
      complexed with mg
    2. 2286475Domain d5grhb_: 5grh B: [329776]
      automated match to d3blxc_
      complexed with mg
  4. Domain(s) for 5gri:
    1. 2286449Domain d5grib_: 5gri B: [329750]
      automated match to d3blxc_
      complexed with cit, mg
    2. 2286458Domain d5gria_: 5gri A: [329759]
      automated match to d3blxo_
      complexed with cit, mg
  5. Domain(s) for 5grl:
    1. 2286477Domain d5grla_: 5grl A: [329778]
      automated match to d3blxo_
      complexed with adp, ict, mg
    2. 2286642Domain d5grlb_: 5grl B: [329943]
      automated match to d3blxc_
      complexed with adp, ict, mg

More info for Species Homo sapiens [TaxId:9606] from c.77.1.0 automated matches

Timeline for Species Homo sapiens [TaxId:9606] from c.77.1.0 automated matches:

  • Species Homo sapiens [TaxId:9606] from c.77.1.0 automated matches appears in periodic updates to SCOPe 2.06 starting on 2017-02-15