Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily) consists of two intertwined (sub)domains related by pseudo dyad; duplication 3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest |
Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) the constituent families form similar dimers |
Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins) the active site is between the two identical subunits |
Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [110715] (18 PDB entries) Uniprot O75874 |
Domain d5lgea1: 5lge A:3-414 [329495] Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2 automated match to d1t0la_ complexed with 6vn, act, edo, nap; mutant |
PDB Entry: 5lge (more details), 2.7 Å
SCOPe Domain Sequences for d5lgea1:
Sequence, based on SEQRES records: (download)
>d5lgea1 c.77.1.1 (A:3-414) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]} kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs gwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgm ynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaq kiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgkt veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl
>d5lgea1 c.77.1.1 (A:3-414) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]} kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs gwvkpiiighhaygdqyratdfvvpgpgkveitytptylhnfeegggvamgmynqdksie dfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwyehrl iddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktveaeaahg tvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietieag fmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl
Timeline for d5lgea1: