Lineage for d5lgea1 (5lge A:3-414)

  1. Root: SCOPe 2.06
  2. 2089713Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2155664Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2155665Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2155666Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
    the active site is between the two identical subunits
  6. 2155760Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)
  7. 2155761Species Human (Homo sapiens) [TaxId:9606] [110715] (18 PDB entries)
    Uniprot O75874
  8. 2155812Domain d5lgea1: 5lge A:3-414 [329495]
    Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2
    automated match to d1t0la_
    complexed with 6vn, act, edo, nap; mutant

Details for d5lgea1

PDB Entry: 5lge (more details), 2.7 Å

PDB Description: crystal structure of human idh1 mutant (r132h) in complex with nadp+ and an inhibitor related to bay 1436032
PDB Compounds: (A:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d5lgea1:

Sequence, based on SEQRES records: (download)

>d5lgea1 c.77.1.1 (A:3-414) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgm
ynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaq
kiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgkt
veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev
sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

Sequence, based on observed residues (ATOM records): (download)

>d5lgea1 c.77.1.1 (A:3-414) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygdqyratdfvvpgpgkveitytptylhnfeegggvamgmynqdksie
dfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwyehrl
iddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktveaeaahg
tvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietieag
fmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

SCOPe Domain Coordinates for d5lgea1:

Click to download the PDB-style file with coordinates for d5lgea1.
(The format of our PDB-style files is described here.)

Timeline for d5lgea1: