SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5lgec1 (5lge C:2-414)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2138632Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2138633Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2138634Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 protein domains)
    the active site is between the two identical subunits
  6. 2138728Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)
  7. 2138729Species Human (Homo sapiens) [TaxId:9606] [110715] (15 PDB entries)
    Uniprot O75874
  8. 2286177Domain d5lgec1: 5lge C:2-414 [329478]
    Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2
    automated match to d1t0la_
    complexed with 6vn, act, edo, nap; mutant

Details for d5lgec1

PDB Entry: 5lge (more details), 2.7 Å

PDB Description: crystal structure of human idh1 mutant (r132h) in complex with nadp+ and an inhibitor related to bay 1436032
PDB Compounds: (C:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d5lgec1:

Sequence, based on SEQRES records: (download)

>d5lgec1 c.77.1.1 (C:2-414) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
skkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaa
eaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlv
sgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamg
mynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfea
qkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgk
tveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanalee
vsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

Sequence, based on observed residues (ATOM records): (download)

>d5lgec1 c.77.1.1 (C:2-414) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
skkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaa
eaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlv
sgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamg
mynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfea
qkiwyehrliddmvaqamkseggfiwacknydgvqsdsvaqgygslgmmtsvlvcpdgkt
veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev
sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

SCOPe Domain Coordinates for d5lgec1:

Click to download the PDB-style file with coordinates for d5lgec1.
(The format of our PDB-style files is described here.)

Timeline for d5lgec1:

  • d5lgec1 appears in periodic updates to SCOPe 2.06 starting on 2017-02-08