Lineage for d5lgec1 (5lge C:2-414)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2138632Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2138633Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2138634Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 protein domains)
    the active site is between the two identical subunits
  6. 2138728Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)
  7. 2138729Species Human (Homo sapiens) [TaxId:9606] [110715] (18 PDB entries)
    Uniprot O75874
  8. 2286177Domain d5lgec1: 5lge C:2-414 [329478]
    Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2
    automated match to d1t0la_
    complexed with 6vn, act, edo, nap; mutant

Details for d5lgec1

PDB Entry: 5lge (more details), 2.7 Å

PDB Description: crystal structure of human idh1 mutant (r132h) in complex with nadp+ and an inhibitor related to bay 1436032
PDB Compounds: (C:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d5lgec1:

Sequence, based on SEQRES records: (download)

>d5lgec1 c.77.1.1 (C:2-414) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
skkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaa
eaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlv
sgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamg
mynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfea
qkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgk
tveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanalee
vsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

Sequence, based on observed residues (ATOM records): (download)

>d5lgec1 c.77.1.1 (C:2-414) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
skkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaa
eaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlv
sgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamg
mynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfea
qkiwyehrliddmvaqamkseggfiwacknydgvqsdsvaqgygslgmmtsvlvcpdgkt
veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev
sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

SCOPe Domain Coordinates for d5lgec1:

Click to download the PDB-style file with coordinates for d5lgec1.
(The format of our PDB-style files is described here.)

Timeline for d5lgec1:

  • d5lgec1 appears in periodic updates to SCOPe 2.06 starting on 2017-02-08