SCOPe 2.06: Domain d5tqfh_: 5tqf H:

Lineage for d5tqfh_ (5tqf H:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Coagulation factor VIIa [50550] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50551] (88 PDB entries)
   Uniprot P08709 213-466 ! Uniprot P08709 213-446

8. Domain d5tqfh_: 5tqf H: [329344]
   Other proteins in same PDB: d5tqfl_
   automated match to d1klih_
   complexed with 7kr, ca, gol, so4

Details for d5tqfh_

PDB Entry: 5tqf, 1.85 Å

PDB Description: factor viia in complex with the inhibitor (11r)-11-[(1- aminoisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-13-methyl-2,13- diazatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaene-3, 12-dione

PDB Compounds: (H:) Factor VIIa (Heavy Chain)

SCOPe Domain Sequences for d5tqfh_:

Sequence, based on SEQRES records:

>d5tqfh_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

Sequence, based on observed residues (ATOM records):

>d5tqfh_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkpniteymfcagysdgs
kdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmrsepr
pgvllrapfp

Timeline for d5tqfh_:

• d5tqfh_ is new in SCOPe 2.06-stable
  
• d5tqfh_ appears in SCOPe 2.07
  
• d5tqfh_ appears in the current release, SCOPe 2.08