SCOPe 2.08: Domain d5tqhd_: 5tqh D:

Lineage for d5tqhd_ (5tqh D:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [110715] (31 PDB entries)
   Uniprot O75874

8. Domain d5tqhd_: 5tqh D: [329032]
   automated match to d1t0la_
   complexed with 7j2, flc, ndp; mutant

Details for d5tqhd_

PDB Entry: 5tqh, 2.2 Å

PDB Description: idh1 r132h mutant in complex with idh889

PDB Compounds: (D:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d5tqhd_:

Sequence, based on SEQRES records:

>d5tqhd_ c.77.1.1 (D:) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaaea
ikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvsg
wvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmy
nqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqk
iwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktv
eaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevs
ietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqa

Sequence, based on observed residues (ATOM records):

>d5tqhd_ c.77.1.1 (D:) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaaea
ikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvsg
wvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmy
nqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqk
iwyehrliddmvaqamkseggfiwacksdsvaqgygslgmmtsvlvcpdgktveaeaahg
tvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietieag
fmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqa

Timeline for d5tqhd_:

• d5tqhd_ first appeared in SCOPe 2.06
  
• d5tqhd_ appears in SCOPe 2.07