SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5hqza_ (5hqz A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2137011Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2137059Species Human (Homo sapiens) [TaxId:9606] [53607] (73 PDB entries)
  8. 2285714Domain d5hqza_: 5hqz A: [329015]
    automated match to d1kmva_
    complexed with 64j, ndp

Details for d5hqza_

PDB Entry: 5hqz (more details), 1.46 Å

PDB Description: fluorine substituted 5-methyl-6-(4'-trifluoromethoxyphenythio) thieno[2,3-d]pyrimidine-2,4-diamine
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d5hqza_:

Sequence; same for both SEQRES and ATOM records: (download)

>d5hqza_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

SCOPe Domain Coordinates for d5hqza_:

Click to download the PDB-style file with coordinates for d5hqza_.
(The format of our PDB-style files is described here.)

Timeline for d5hqza_:

  • d5hqza_ appears in periodic updates to SCOPe 2.06 starting on 2017-01-26