SCOPe 2.06: Domain d5tqha_: 5tqh A:

Lineage for d5tqha_ (5tqh A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [110715] (18 PDB entries)
   Uniprot O75874

8. Domain d5tqha_: 5tqh A: [329009]
   automated match to d1t0la_
   complexed with 7j2, flc, ndp; mutant

Details for d5tqha_

PDB Entry: 5tqh, 2.2 Å

PDB Description: idh1 r132h mutant in complex with idh889

PDB Compounds: (A:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d5tqha_:

Sequence, based on SEQRES records:

>d5tqha_ c.77.1.1 (A:) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgm
ynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaq
kiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgkt
veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev
sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqa

Sequence, based on observed residues (ATOM records):

>d5tqha_ c.77.1.1 (A:) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynq
dksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiw
yehrliddmvaqamkseggfiwacknsdsvaqgygslgmmtsvlvcpdgktveaeaahgt
vtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietieagf
mtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqa

Timeline for d5tqha_:

• d5tqha_ is new in SCOPe 2.06-stable
  
• d5tqha_ appears in SCOPe 2.07
  
• d5tqha_ appears in the current release, SCOPe 2.08