SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5hiac_ (5hia C:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2128255Fold c.61: PRTase-like [53270] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
  4. 2128256Superfamily c.61.1: PRTase-like [53271] (3 families) (S)
  5. 2128257Family c.61.1.1: Phosphoribosyltransferases (PRTases) [53272] (16 protein domains)
  6. 2128349Protein Hypoxanthine-guanine PRTase (HGPRTase) [53283] (3 species)
  7. 2128350Species Human (Homo sapiens) [TaxId:9606] [53284] (18 PDB entries)
  8. 2285504Domain d5hiac_: 5hia C: [328805]
    automated match to d4raoa_
    complexed with mg, ypg

Details for d5hiac_

PDB Entry: 5hia (more details), 1.77 Å

PDB Description: human hypoxanthine-guanine phosphoribosyltransferase in complex with [3r,4r]-4-guanin-9-yl-3-((s)-2-hydroxy-2-phosphonoethyl)oxy-1-n- (phosphonopropionyl)pyrrolidine
PDB Compounds: (C:) hypoxanthine-guanine phosphoribosyltransferase

SCOPe Domain Sequences for d5hiac_:

Sequence, based on SEQRES records: (download)

>d5hiac_ c.61.1.1 (C:) Hypoxanthine-guanine PRTase (HGPRTase) {Human (Homo sapiens) [TaxId: 9606]}
spgvvisddepgydldlfaipnhyaedlervfiphglimdrterlardvmkemgghhiva
lcvlkggykffadlldyikalnrnsdrsipmtvdfirlksycndqstgdikviggddlst
ltgknvlivediidtgktmqtllslvrqynpkmvkvasllvkrtprsvgykpdfvgfeip
dkfvvgyaldyneyfrdlnhvavisetgkakyka

Sequence, based on observed residues (ATOM records): (download)

>d5hiac_ c.61.1.1 (C:) Hypoxanthine-guanine PRTase (HGPRTase) {Human (Homo sapiens) [TaxId: 9606]}
spgvvisddepgydldlfaipnhyaedlervfiphglimdrterlardvmkemgghhiva
lcvlkggykffadlldyikalnrnsdrsipmtvdfirlkgdikviggddlstltgknvli
vediidtgktmqtllslvrqynpkmvkvasllvkrtprsvgykpdfvgfeipdkfvvgya
ldyneyfrdlnhvavisetgkakyka

SCOPe Domain Coordinates for d5hiac_:

Click to download the PDB-style file with coordinates for d5hiac_.
(The format of our PDB-style files is described here.)

Timeline for d5hiac_:

  • d5hiac_ appears in periodic updates to SCOPe 2.06 starting on 2017-01-19