Lineage for d5hf2x_ (5hf2 X:)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2477518Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2477519Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2477520Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2477549Protein Dihydrofolate reductase, prokaryotic type [53599] (8 species)
  7. 2477692Species Staphylococcus aureus [TaxId:1280] [188976] (25 PDB entries)
  8. 2477704Domain d5hf2x_: 5hf2 X: [328785]
    automated match to d3sqyx_
    complexed with gol, u75, xnp

Details for d5hf2x_

PDB Entry: 5hf2 (more details), 1.81 Å

PDB Description: staphylococcus aureus dihydrofolate reductase complexed with cyclized alpha-nadph anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop- 2-yn-1-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (ucp1175)
PDB Compounds: (X:) dihydrofolate reductase

SCOPe Domain Sequences for d5hf2x_:

Sequence; same for both SEQRES and ATOM records: (download)

>d5hf2x_ c.71.1.1 (X:) Dihydrofolate reductase, prokaryotic type {Staphylococcus aureus [TaxId: 1280]}
tlsilvahdlqrvigfenqlpwhlpndlkhvkklstghtlvmgrktfesigkplpnrrnv
vltsdtsfnvegvdvihsiediyqlpghvfifggqtlfeemidkvddmyitviegkfrgd
tffppytfedwevassvegkldekntiphtflhlirk

SCOPe Domain Coordinates for d5hf2x_:

Click to download the PDB-style file with coordinates for d5hf2x_.
(The format of our PDB-style files is described here.)

Timeline for d5hf2x_: