SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5ieza1 (5iez A:172-321)

  1. Root: SCOPe 2.06
  2. 2223823Class f: Membrane and cell surface proteins and peptides [56835] (59 folds)
  3. 2223824Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
    multi-helical domains of various folds which is thought to unfold in the membrane
  4. 2223896Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families) (S)
    PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain
  5. 2223897Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 protein domains)
    Pfam PF00452
  6. 2224027Protein automated matches [190236] (4 species)
    not a true protein
  7. 2224028Species Human (Homo sapiens) [TaxId:9606] [188722] (47 PDB entries)
  8. 2285332Domain d5ieza1: 5iez A:172-321 [328633]
    Other proteins in same PDB: d5ieza2, d5iezd2
    automated match to d2kbwa_
    complexed with 6al

Details for d5ieza1

PDB Entry: 5iez (more details), 2.6 Å

PDB Description: discovery of potent myeloid cell leukemia-1 (mcl-1) inhibitors using structure-based design
PDB Compounds: (A:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d5ieza1:

Sequence; same for both SEQRES and ATOM records: (download)

>d5ieza1 f.1.4.1 (A:172-321) automated matches {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhv

SCOPe Domain Coordinates for d5ieza1:

Click to download the PDB-style file with coordinates for d5ieza1.
(The format of our PDB-style files is described here.)

Timeline for d5ieza1:

  • d5ieza1 appears in periodic updates to SCOPe 2.06 starting on 2017-01-19