SCOPe 2.08: Domain d5iezc_: 5iez C:

Lineage for d5iezc_ (5iez C:)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [188549] (62 PDB entries)

8. Domain d5iezc_: 5iez C: [328549]
   Other proteins in same PDB: d5ieza2, d5iezd2
   automated match to d2kbwa_
   complexed with 6al

Details for d5iezc_

PDB Entry: 5iez, 2.6 Å

PDB Description: discovery of potent myeloid cell leukemia-1 (mcl-1) inhibitors using structure-based design

PDB Compounds: (C:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d5iezc_:

Sequence; same for both SEQRES and ATOM records:

>d5iezc_ f.1.4.1 (C:) EAT/MCL-1 (Myeloid cell leukemia sequence 1) {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhved

Timeline for d5iezc_:

• d5iezc_ first appeared in SCOPe 2.06
  
• d5iezc_ appears in SCOPe 2.07