Lineage for d5iezd1 (5iez D:172-323)

  1. Root: SCOPe 2.06
  2. 2223823Class f: Membrane and cell surface proteins and peptides [56835] (59 folds)
  3. 2223824Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
    multi-helical domains of various folds which is thought to unfold in the membrane
  4. 2223896Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families) (S)
    PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain
  5. 2223897Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 protein domains)
    Pfam PF00452
  6. 2224027Protein automated matches [190236] (4 species)
    not a true protein
  7. 2224028Species Human (Homo sapiens) [TaxId:9606] [188722] (49 PDB entries)
  8. 2285216Domain d5iezd1: 5iez D:172-323 [328517]
    Other proteins in same PDB: d5ieza2, d5iezd2
    automated match to d2kbwa_
    complexed with 6al

Details for d5iezd1

PDB Entry: 5iez (more details), 2.6 Å

PDB Description: discovery of potent myeloid cell leukemia-1 (mcl-1) inhibitors using structure-based design
PDB Compounds: (D:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d5iezd1:

Sequence, based on SEQRES records: (download)

>d5iezd1 f.1.4.1 (D:172-323) automated matches {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhved

Sequence, based on observed residues (ATOM records): (download)

>d5iezd1 f.1.4.1 (D:172-323) automated matches {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdgatsrkaletlrrvgdgvqrnhetafqgmlrkldik
neddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitdvl
vrtkrdwlvkqrgwdgfveffhved

SCOPe Domain Coordinates for d5iezd1:

Click to download the PDB-style file with coordinates for d5iezd1.
(The format of our PDB-style files is described here.)

Timeline for d5iezd1:

  • d5iezd1 appears in periodic updates to SCOPe 2.06 starting on 2017-01-19