SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5cira_ (5cir A:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2041369Fold b.22: TNF-like [49841] (1 superfamily)
    sandwich, 10 strands in 2 sheets; jelly-roll
  4. 2041370Superfamily b.22.1: TNF-like [49842] (2 families) (S)
  5. 2041371Family b.22.1.1: TNF-like [49843] (15 protein domains)
  6. 2041626Protein automated matches [190204] (3 species)
    not a true protein
  7. 2041627Species Human (Homo sapiens) [TaxId:9606] [186956] (10 PDB entries)
  8. 2285203Domain d5cira_: 5cir A: [328504]
    automated match to d1d4vb_
    complexed with cl, zn

Details for d5cira_

PDB Entry: 5cir (more details), 3 Å

PDB Description: crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
PDB Compounds: (A:) Tumor necrosis factor ligand superfamily member 10

SCOPe Domain Sequences for d5cira_:

Sequence, based on SEQRES records: (download)

>d5cira_ b.22.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pqrvaahitgtrgrsntlsspnsknekalgrkinswessrsghsflsnlhlrngelvihe
kgfyyiysqtyfrfqeeikentkndkqmvqyiykytsypdpillmksarnscwskdaeyg
lysiyqggifelkendrifvsvtnehlidmdheasffgaflv

Sequence, based on observed residues (ATOM records): (download)

>d5cira_ b.22.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pqrvaahitgtrekalgrkinswessrsghsflsnlhlrngelvihekgfyyiysqtyfr
fqeeikentkndkqmvqyiykytsypdpillmksarnscwskdaeyglysiyqggifelk
endrifvsvtnehlidmdheasffgaflv

SCOPe Domain Coordinates for d5cira_:

Click to download the PDB-style file with coordinates for d5cira_.
(The format of our PDB-style files is described here.)

Timeline for d5cira_:

  • d5cira_ appears in periodic updates to SCOPe 2.06 starting on 2017-01-18