SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5tq6a_ (5tq6 A:)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2199100Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2199101Protein automated matches [190417] (25 species)
    not a true protein
  7. 2199241Species Human (Homo sapiens) [TaxId:9606] [187294] (768 PDB entries)
  8. 2285124Domain d5tq6a_: 5tq6 A: [328425]
    automated match to d4e4ma_
    complexed with 7gv

Details for d5tq6a_

PDB Entry: 5tq6 (more details), 2.06 Å

PDB Description: design and synthesis of a pan-jak kinase inhibitor clinical candidate (pf-06263276) suitable for inhaled and topical delivery for the treatment of inflammatory diseases of the lungs and skin
PDB Compounds: (A:) Tyrosine-protein kinase JAK2

SCOPe Domain Sequences for d5tq6a_:

Sequence, based on SEQRES records: (download)

>d5tq6a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqick
gmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwya
peslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqsivthliell
knngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

Sequence, based on observed residues (ATOM records): (download)

>d5tq6a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickgmey
lgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkespifwyapesltes
kfsvasdvwsfgvvlyelftyieksksppaefmrmisivthliellknngrlprpdgcpd
eiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

SCOPe Domain Coordinates for d5tq6a_:

Click to download the PDB-style file with coordinates for d5tq6a_.
(The format of our PDB-style files is described here.)

Timeline for d5tq6a_:

  • d5tq6a_ appears in periodic updates to SCOPe 2.06 starting on 2017-01-13