SCOPe 2.06: Domain d5tq7b_: 5tq7 B:

Lineage for d5tq7b_ (5tq7 B:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (25 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (882 PDB entries)

8. Domain d5tq7b_: 5tq7 B: [328389]
   automated match to d4e4ma_
   complexed with 7gt

Details for d5tq7b_

PDB Entry: 5tq7, 2.1 Å

PDB Description: design and synthesis of a pan-jak kinase inhibitor clinical candidate (pf-06263276) suitable for inhaled and topical delivery for the treatment of inflammatory diseases of the lungs and skin

PDB Compounds: (B:) Tyrosine-protein kinase JAK2

SCOPe Domain Sequences for d5tq7b_:

Sequence, based on SEQRES records:

>d5tq7b_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqick
gmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwya
peslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqsivthliell
knngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqvrdnmag

Sequence, based on observed residues (ATOM records):

>d5tq7b_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qfeerhlkflqqlgkgnfgsvemcrydplntgevvavkklqhhlrdfereieilkslqhd
nivkykgvcyrnlklimeylpygslrdylqkhkeridhikllqytsqickgmeylgtkry
ihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvgespifwyapeslteskfsvas
dvwsfgvvlyelftyieksksppaefmrmigsivthliellknngrlprpdgcpdeiymi
mtecwnnnvnqrpsfrdlalrvdqvrdnmag

Timeline for d5tq7b_:

• d5tq7b_ is new in SCOPe 2.06-stable
  
• d5tq7b_ appears in SCOPe 2.07
  
• d5tq7b_ appears in the current release, SCOPe 2.08