Lineage for d5tq7a_ (5tq7 A:)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2199100Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2199101Protein automated matches [190417] (25 species)
    not a true protein
  7. 2199241Species Human (Homo sapiens) [TaxId:9606] [187294] (825 PDB entries)
  8. 2285062Domain d5tq7a_: 5tq7 A: [328363]
    automated match to d4e4ma_
    complexed with 7gt

Details for d5tq7a_

PDB Entry: 5tq7 (more details), 2.1 Å

PDB Description: design and synthesis of a pan-jak kinase inhibitor clinical candidate (pf-06263276) suitable for inhaled and topical delivery for the treatment of inflammatory diseases of the lungs and skin
PDB Compounds: (A:) Tyrosine-protein kinase JAK2

SCOPe Domain Sequences for d5tq7a_:

Sequence, based on SEQRES records: (download)

>d5tq7a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereie
ilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqi
ckgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifw
yapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqsivthlie
llknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqvrdnmag

Sequence, based on observed residues (ATOM records): (download)

>d5tq7a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhehlrdfereieilk
slqhdnivkykgvcysagnlklimeylpygslrdylqkhkeridhikllqytsqickgme
ylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvespifwyapesltes
kfsvasdvwsfgvvlyelftyieksksppaefmrmigsivthliellknngrlprpdgcp
deiymimtecwnnnvnqrpsfrdlalrvdqvrdnmag

SCOPe Domain Coordinates for d5tq7a_:

Click to download the PDB-style file with coordinates for d5tq7a_.
(The format of our PDB-style files is described here.)

Timeline for d5tq7a_:

  • d5tq7a_ appears in periodic updates to SCOPe 2.06 starting on 2017-01-12