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Lineage for d5tq4a_ (5tq4 A:)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2199100Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2199101Protein automated matches [190417] (25 species)
    not a true protein
  7. 2199241Species Human (Homo sapiens) [TaxId:9606] [187294] (768 PDB entries)
  8. 2284965Domain d5tq4a_: 5tq4 A: [328266]
    automated match to d4e4ma_
    complexed with 7gy

Details for d5tq4a_

PDB Entry: 5tq4 (more details), 2.3 Å

PDB Description: design and synthesis of a pan-jak kinase inhibitor clinical candidate (pf-06263276) suitable for inhaled and topical delivery for the treatment of inflammatory diseases of the lungs and skin
PDB Compounds: (A:) Tyrosine-protein kinase JAK2

SCOPe Domain Sequences for d5tq4a_:

Sequence; same for both SEQRES and ATOM records: (download)

>d5tq4a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereie
ilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqi
ckgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifw
yapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqsivthlie
llknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

SCOPe Domain Coordinates for d5tq4a_:

Click to download the PDB-style file with coordinates for d5tq4a_.
(The format of our PDB-style files is described here.)

Timeline for d5tq4a_:

  • d5tq4a_ appears in periodic updates to SCOPe 2.06 starting on 2017-01-12