SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5tg2a_ (5tg2 A:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2055629Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2055630Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2057856Family b.47.1.4: Viral cysteine protease of trypsin fold [50603] (5 protein domains)
  6. 2058054Protein automated matches [190384] (19 species)
    not a true protein
  7. 2270301Species Norwalk virus [TaxId:524364] [313606] (10 PDB entries)
  8. 2284900Domain d5tg2a_: 5tg2 A: [328201]
    automated match to d2fyqa_
    complexed with v69

Details for d5tg2a_

PDB Entry: 5tg2 (more details), 1.75 Å

PDB Description: 1.75 a resolution structure of norovirus 3cl protease in complex with the a n-pentyl substituted macrocyclic inhibitor (17-mer)
PDB Compounds: (A:) 3C-like protease

SCOPe Domain Sequences for d5tg2a_:

Sequence, based on SEQRES records: (download)

>d5tg2a_ b.47.1.4 (A:) automated matches {Norwalk virus [TaxId: 524364]}
pptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqfrfs
kkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsgml
ltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa

Sequence, based on observed residues (ATOM records): (download)

>d5tg2a_ b.47.1.4 (A:) automated matches {Norwalk virus [TaxId: 524364]}
pptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqfrfs
kkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsgml
ltganakgdcgapyvhkrgndwvvcgvhaaatgntvvcavqa

SCOPe Domain Coordinates for d5tg2a_:

Click to download the PDB-style file with coordinates for d5tg2a_.
(The format of our PDB-style files is described here.)

Timeline for d5tg2a_:

  • d5tg2a_ appears in periodic updates to SCOPe 2.06 starting on 2017-01-12