SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5thot_ (5tho T:)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2201124Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
    4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
  4. 2201125Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families) (S)
    N-terminal residue provides two catalytic groups, nucleophile and proton donor
  5. 2201309Family d.153.1.4: Proteasome subunits [56251] (4 protein domains)
  6. 2203920Protein automated matches [190144] (11 species)
    not a true protein
  7. 2284857Species Mycobacterium tuberculosis [TaxId:419947] [328158] (1 PDB entry)
  8. 2284867Domain d5thot_: 5tho T: [328168]
    automated match to d2fhh1_
    complexed with 7c7

Details for d5thot_

PDB Entry: 5tho (more details), 3 Å

PDB Description: crystal structure of mycobacterium tuberculosis proteasome in complex with n,c-capped dipeptide inhibitor pks2205
PDB Compounds: (T:) Proteasome subunit alpha

SCOPe Domain Sequences for d5thot_:

Sequence, based on SEQRES records: (download)

>d5thot_ d.153.1.4 (T:) automated matches {Mycobacterium tuberculosis [TaxId: 419947]}
meqamrerselarkgiaraksvvalayaggvlfvaenpsrslqkiselydrvgfaaagkf
nefdnlrrggiqfadtrgyaydrrdvtgrqlanvyaqtlgtifteqakpyevelcvaeva
hygetkrpelyritydgsiadephfvvmggttepianalkesyaenasltdalriavaal
ragsadtsggdqptlgvaslevavldanrprrafrritgsalqallv

Sequence, based on observed residues (ATOM records): (download)

>d5thot_ d.153.1.4 (T:) automated matches {Mycobacterium tuberculosis [TaxId: 419947]}
meqamrerselarkgiaraksvvalayaggvlfvaenpsrslqkiselydrvgfaaagkf
nefdnlrrggiqfadtrgyaydrrdvtgrqlanvyaqtlgtifteqakpyevelcvaeva
hygetkrpelyritydgsiadephfvvmggttepianalkesyaenasltdalriavaal
ragtlgvaslevavldanrprrafrritgsalqallv

SCOPe Domain Coordinates for d5thot_:

Click to download the PDB-style file with coordinates for d5thot_.
(The format of our PDB-style files is described here.)

Timeline for d5thot_:

  • d5thot_ appears in periodic updates to SCOPe 2.06 starting on 2017-01-12