SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5lqea1 (5lqe A:1-295)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2195690Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 protein domains)
    members organized in the groups and subfamiles specified by the comments
  6. 2196228Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  7. 2196229Species Human (Homo sapiens) [TaxId:9606] [88856] (373 PDB entries)
    Uniprot P24941
  8. 2284800Domain d5lqea1: 5lqe A:1-295 [328101]
    Other proteins in same PDB: d5lqea2, d5lqeb1, d5lqeb2, d5lqec2, d5lqed1, d5lqed2
    automated match to d1giia_
    complexed with 72l

Details for d5lqea1

PDB Entry: 5lqe (more details), 2.97 Å

PDB Description: cdk2/cyclin a in complex with compound 73
PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d5lqea1:

Sequence; same for both SEQRES and ATOM records: (download)

>d5lqea1 d.144.1.7 (A:1-295) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvph

SCOPe Domain Coordinates for d5lqea1:

Click to download the PDB-style file with coordinates for d5lqea1.
(The format of our PDB-style files is described here.)

Timeline for d5lqea1:

  • d5lqea1 appears in periodic updates to SCOPe 2.06 starting on 2017-01-12