SCOPe 2.08: Domain d5tkda_: 5tkd A:

Lineage for d5tkda_ (5tkd A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d5tkda_: 5tkd A: [327723]
   automated match to d4l00b_
   complexed with 7gl, so4

Details for d5tkda_

PDB Entry: 5tkd, 1.92 Å

PDB Description: crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with 6-[(3,5-dimethylphe nyl)amino]-8- (methylamino) imidazo[1,2-b]pyridazine-3-carbo xamide

PDB Compounds: (A:) Non-receptor tyrosine-protein kinase TYK2

SCOPe Domain Sequences for d5tkda_:

Sequence, based on SEQRES records:

>d5tkda_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
fhrvdqkeitqlshlgqgtrtnvyegrlrvegsgdpeegkmddedplvpgrdrgqelrvv
lkvldpshhdialafyetaslmsqvshthlafvhgvcvrgpenimvteyvehgpldvwlr
rerghvpmawkmvvaqqlasalsylenknlvhgnvcgrnillarlglaegtspfiklsdp
gvglgalsreerveripwlapeclpgganslstamdkwgfgatlleicfdgeaplqsrsp
sekehfyqrqhrlpepscpqlatltsqcltyeptqrpsfrtilrdl

Sequence, based on observed residues (ATOM records):

>d5tkda_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
fhrvdqkeitqlshlgqgtrtnvyegrlrlrvvlkvldpshhdialafyetaslmsqvsh
thlafvhgvcvrgpenimvteyvehgpldvwlrrerghvpmawkmvvaqqlasalsylen
knlvhgnvcgrnillarlglaegtspfiklsdpgvglgalsreerveripwlapeclpst
amdkwgfgatlleicfdgeaplrspsekehfyqrqhrlpepslatltsqcltyeptqrps
frtilrdl

Timeline for d5tkda_:

• d5tkda_ first appeared in SCOPe 2.06
  
• d5tkda_ appears in SCOPe 2.07