SCOPe 2.06: Domain d5thtc_: 5tht C:

Lineage for d5thtc_ (5tht C:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.42: Arginase/deacetylase [52767] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456

4. Superfamily c.42.1: Arginase/deacetylase [52768] (3 families)

5. Family c.42.1.2: Histone deacetylase, HDAC [52773] (4 proteins)
   automatically mapped to Pfam PF00850

6. Protein automated matches [190786] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188039] (33 PDB entries)

8. Domain d5thtc_: 5tht C: [327544]
   Other proteins in same PDB: d5thta2, d5thtb2
   automated match to d2v5wb_
   complexed with b3n, edo, k, zn

Details for d5thtc_

PDB Entry: 5tht, 2.41 Å

PDB Description: crystal structure of g303a hdac8 in complex with m344

PDB Compounds: (C:) Histone deacetylase 8

SCOPe Domain Sequences for d5thtc_:

Sequence, based on SEQRES records:

>d5thtc_ c.42.1.2 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmckv
ainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsfts
kvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyq
afnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilgaggynlantar
cwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnl
khvv

Sequence, based on observed residues (ATOM records):

>d5thtc_ c.42.1.2 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqeeygldcpategifdyaaaiggatitaaqclidgmckvainwsggwhha
kkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtvslhkfs
pgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnpkavvlql
gadtiagdpmcsfnmtpvgigkclkyilqwqlatlilgaggynlantarcwtyltgvilg
ktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvv

Timeline for d5thtc_:

• d5thtc_ is new in SCOPe 2.06-stable
  
• d5thtc_ appears in SCOPe 2.07
  
• d5thtc_ appears in the current release, SCOPe 2.08