SCOPe 2.08: Domain d5l58a_: 5l58 A:

Lineage for d5l58a_ (5l58 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [110715] (31 PDB entries)
   Uniprot O75874

8. Domain d5l58a_: 5l58 A: [327177]
   automated match to d1t0la_
   complexed with 6mx, ndp

Details for d5l58a_

PDB Entry: 5l58, 3.04 Å

PDB Description: crystal structure of iso-citrate dehydrogenase 1 [idh1 (r132h)] in complex with a novel inhibitor (compound 2)

PDB Compounds: (A:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d5l58a_:

Sequence, based on SEQRES records:

>d5l58a_ c.77.1.1 (A:) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdaarveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgm
ynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfaaa
aiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgkt
veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev
sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

Sequence, based on observed residues (ATOM records):

>d5l58a_ c.77.1.1 (A:) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdaarveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygatdfvvpgpeittylvggvamgmynqdksiedfahssfqmalskgw
plylstkkydgrfkdifqeiydkqyksqfaaaaiwyehrliddmvaqamkseggfiwack
nyvaqgygslgmmtsvlvcpdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtr
glahrakldnnkelaffanaleevsietieagfmtkdlaacikglpnvqrsdylntfefm
dklgenlkiklaqakl

Timeline for d5l58a_:

• d5l58a_ first appeared in SCOPe 2.06
  
• d5l58a_ appears in SCOPe 2.07