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Lineage for d5l58a_ (5l58 A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2138632Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2138633Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2138634Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 protein domains)
    the active site is between the two identical subunits
  6. 2138728Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)
  7. 2138729Species Human (Homo sapiens) [TaxId:9606] [110715] (15 PDB entries)
    Uniprot O75874
  8. 2283876Domain d5l58a_: 5l58 A: [327177]
    automated match to d1t0la_
    complexed with 6mx, ndp

Details for d5l58a_

PDB Entry: 5l58 (more details), 3.04 Å

PDB Description: crystal structure of iso-citrate dehydrogenase 1 [idh1 (r132h)] in complex with a novel inhibitor (compound 2)
PDB Compounds: (A:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d5l58a_:

Sequence, based on SEQRES records: (download)

>d5l58a_ c.77.1.1 (A:) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdaarveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgm
ynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfaaa
aiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgkt
veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev
sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

Sequence, based on observed residues (ATOM records): (download)

>d5l58a_ c.77.1.1 (A:) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdaarveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygatdfvvpgpeittylvggvamgmynqdksiedfahssfqmalskgw
plylstkkydgrfkdifqeiydkqyksqfaaaaiwyehrliddmvaqamkseggfiwack
nyvaqgygslgmmtsvlvcpdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtr
glahrakldnnkelaffanaleevsietieagfmtkdlaacikglpnvqrsdylntfefm
dklgenlkiklaqakl

SCOPe Domain Coordinates for d5l58a_:

Click to download the PDB-style file with coordinates for d5l58a_.
(The format of our PDB-style files is described here.)

Timeline for d5l58a_:

  • d5l58a_ appears in periodic updates to SCOPe 2.06 starting on 2016-12-15