SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5te8a_ (5te8 A:)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2004931Fold a.104: Cytochrome P450 [48263] (1 superfamily)
    multihelical
  4. 2004932Superfamily a.104.1: Cytochrome P450 [48264] (2 families) (S)
  5. 2004933Family a.104.1.1: Cytochrome P450 [48265] (23 protein domains)
  6. 2005432Protein automated matches [190068] (9 species)
    not a true protein
  7. 2005449Species Human (Homo sapiens) [TaxId:9606] [189507] (35 PDB entries)
  8. 2283783Domain d5te8a_: 5te8 A: [327084]
    automated match to d1w0ea_
    complexed with 08j, hem

Details for d5te8a_

PDB Entry: 5te8 (more details), 2.7 Å

PDB Description: crystal structure of the midazolam-bound human cyp3a4
PDB Compounds: (A:) cytochrome p450 3a4

SCOPe Domain Sequences for d5te8a_:

Sequence, based on SEQRES records: (download)

>d5te8a_ a.104.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
aylygthshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpv
laitdpdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgk
lkemvpiiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqd
pfventkkllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrl
edtqkhrvdflqlmidsqnsketeshkalsdlelvaqsiififagyettssvlsfimyel
athpdvqqklqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdv
eingmfipkgvvvmipsyalhrdpkywtepekflperfskknkdnidpyiytpfgsgprn
cigmrfalmnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesrd

Sequence, based on observed residues (ATOM records): (download)

>d5te8a_ a.104.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
aylygthshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpv
laitdpdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgk
lkemvpiiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqd
pfventkkllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrl
dtqkhrvdflqlmidsqnshkalsdlelvaqsiififagyettssvlsfimyelathpdv
qqklqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdveingmf
ipkgvvvmipsyalhrdpkywtepekflperfskknkdnidpyiytpfgsgprncigmrf
almnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesrd

SCOPe Domain Coordinates for d5te8a_:

Click to download the PDB-style file with coordinates for d5te8a_.
(The format of our PDB-style files is described here.)

Timeline for d5te8a_:

  • d5te8a_ appears in periodic updates to SCOPe 2.06 starting on 2016-12-08