SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5tr6a2 (5tr6 A:636-639)

  1. Root: SCOPe 2.06
  2. 2245868Class l: Artifacts [310555] (1 fold)
  3. 2245869Fold l.1: Tags [310573] (1 superfamily)
  4. 2245870Superfamily l.1.1: Tags [310607] (1 family) (S)
  5. 2245871Family l.1.1.1: Tags [310682] (2 protein domains)
  6. 2245872Protein C-terminal Tags [310895] (1 species)
  7. 2245873Species Synthetic [311502] (4201 PDB entries)
  8. 2283537Domain d5tr6a2: 5tr6 A:636-639 [326838]
    Other proteins in same PDB: d5tr6a1
    complexed with 7kg, edo

Details for d5tr6a2

PDB Entry: 5tr6 (more details), 1.93 Å

PDB Description: discovery of tak-659, an orally available investigational inhibitor of spleen tyrosine kinase (syk)
PDB Compounds: (A:) Tyrosine-protein kinase SYK

SCOPe Domain Sequences for d5tr6a2:

Sequence; same for both SEQRES and ATOM records: (download)

>d5tr6a2 l.1.1.1 (A:636-639) C-terminal Tags {Synthetic}
hhhh

SCOPe Domain Coordinates for d5tr6a2:

Click to download the PDB-style file with coordinates for d5tr6a2.
(The format of our PDB-style files is described here.)

Timeline for d5tr6a2:

  • d5tr6a2 appears in periodic updates to SCOPe 2.06 starting on 2016-12-01

View in 3D
Domains from same chain:
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d5tr6a1