Lineage for d5tr6a1 (5tr6 A:362-635)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 protein domains)
    members organized in the groups and subfamiles specified by the comments
  6. 2545010Protein Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  7. 2545011Species Human (Homo sapiens) [TaxId:9606] [118132] (59 PDB entries)
    Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)
  8. 2545045Domain d5tr6a1: 5tr6 A:362-635 [326837]
    Other proteins in same PDB: d5tr6a2
    automated match to d3tuca_
    complexed with 7kg, edo

Details for d5tr6a1

PDB Entry: 5tr6 (more details), 1.93 Å

PDB Description: discovery of tak-659, an orally available investigational inhibitor of spleen tyrosine kinase (syk)
PDB Compounds: (A:) Tyrosine-protein kinase SYK

SCOPe Domain Sequences for d5tr6a1:

Sequence, based on SEQRES records: (download)

>d5tr6a1 d.144.1.7 (A:362-635) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
evyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaea
nvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmg
mkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyap
ecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcprem
ydlmnlcwtydvenrpgfaavelrlrnyyydvvn

Sequence, based on observed residues (ATOM records): (download)

>d5tr6a1 d.144.1.7 (A:362-635) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
evyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilpalkdellaeanvmqql
dnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkylee
snfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyapecinyy
kfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnl
cwtydvenrpgfaavelrlrnyyydvvn

SCOPe Domain Coordinates for d5tr6a1:

Click to download the PDB-style file with coordinates for d5tr6a1.
(The format of our PDB-style files is described here.)

Timeline for d5tr6a1:

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Domains from same chain:
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d5tr6a2