SCOPe 2.06: Domain d5tria_: 5tri A:

Lineage for d5tria_ (5tri A:)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (29 species)
   not a true protein

7. Species Hepatitis C virus [TaxId:11103] [187048] (44 PDB entries)

8. Domain d5tria_: 5tri A: [326814]
   automated match to d3q0za_
   protein/RNA complex; complexed with 23e, 7hm, so4

Details for d5tria_

PDB Entry: 5tri, 2.3 Å

PDB Description: crystal structure of the hepatitis c virus ns5b rna-dependent rna polymerase in complex with 3-[(4-chlorophenyl)methoxy]-2-(1-oxo-1,3- dihydro-2h-isoindol-2-yl)benzoic acid

PDB Compounds: (A:) NS5B RNA-dependent RNA polymerase

SCOPe Domain Sequences for d5tria_:

Sequence, based on SEQRES records:

>d5tria_ e.8.1.4 (A:) automated matches {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeetklpinalsnsllrhhnlvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsarskfgygakdvrnlsskavnhir
svwkdlledtetpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspgqrveflvnawkakkcpmgfaydtrcfdstvtendirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkaa
aacraaklqdctmlvcgddlvvicesagtqedeaslrafteamtrysappgdppkpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiiqrlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavrtklkltpip
aasqldlsswfvagysggdiyhsl

Sequence, based on observed residues (ATOM records):

>d5tria_ e.8.1.4 (A:) automated matches {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcvyattsrsaslrqkkvtfdrlqvlddhyrdvlkemkakastvkakl
lsveeackltpphsarskfgygakdvrnlsskavnhirsvwkdlledtetpidttimakn
evfcvqpekggrkparlivfpdlgvrvcekmalydvvstlpqavmgssygfqyspgqrve
flvnawkakkcpmgfaydtrcfdstvtendirveesiyqccdlapearqairslterlyi
ggpltnskgqncgyrrcrasgvlttscgntltcylkaaaacraaklqdctmlvcgddlvv
icesagtqedeaslrafteamtrysappgdppkpeydlelitscssnvsvahdasgkrvy
yltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqleka
ldcqiygacysiepldlpqiiqrlhglsafslhsyspgeinrvasclrklgvpplrvwrh
rarsvrarllsqggraatcgkylfnwavrtklkltpipaasqldlsswfvagysggdiyh
sl

Timeline for d5tria_:

• d5tria_ is new in SCOPe 2.06-stable
  
• d5tria_ appears in SCOPe 2.07
  
• d5tria_ appears in the current release, SCOPe 2.08