SCOPe 2.08: Domain d5hora_: 5hor A:

Lineage for d5hora_ (5hor A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (67 PDB entries)

8. Domain d5hora_: 5hor A: [326525]
   automated match to d1r0pa_
   complexed with 63k

Details for d5hora_

PDB Entry: 5hor, 2.2 Å

PDB Description: crystal structure of c-met-m1250t in complex with sar125844.

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d5hora_:

Sequence, based on SEQRES records:

>d5hora_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
qavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavkslnritdigevsq
fltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnethnptvkdlig
fglqvakgmkflaskkfvhrdlaarncmldekftvkvadfglardmydkefdsvhnktga
klpvkwtaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrll
qpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvnaty

Sequence, based on observed residues (ATOM records):

>d5hora_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
qavqhvvigpgcvyhgtlkihcavksvsqfltegiimkdfshpnvlsllgiclrsegspl
vvlpymkhgdlrnfirnethnptvkdligfglqvakgmkflaskkfvhrdlaarncmlde
kftvkvadfglardmlpvkwtaleslqtqkfttksdvwsfgvllwelmtrgappypdvnt
fditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehy
vhvnaty

Timeline for d5hora_:

• d5hora_ first appeared in SCOPe 2.06
  
• d5hora_ appears in SCOPe 2.07