SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5hora_ (5hor A:)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2195690Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 protein domains)
    members organized in the groups and subfamiles specified by the comments
  6. 2197126Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
    PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase
  7. 2197127Species Human (Homo sapiens) [TaxId:9606] [103301] (49 PDB entries)
  8. 2283224Domain d5hora_: 5hor A: [326525]
    automated match to d1r0pa_
    complexed with 63k

Details for d5hora_

PDB Entry: 5hor (more details), 2.2 Å

PDB Description: crystal structure of c-met-m1250t in complex with sar125844.
PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d5hora_:

Sequence, based on SEQRES records: (download)

>d5hora_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
qavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavkslnritdigevsq
fltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnethnptvkdlig
fglqvakgmkflaskkfvhrdlaarncmldekftvkvadfglardmydkefdsvhnktga
klpvkwtaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrll
qpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvnaty

Sequence, based on observed residues (ATOM records): (download)

>d5hora_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
qavqhvvigpgcvyhgtlkihcavksvsqfltegiimkdfshpnvlsllgiclrsegspl
vvlpymkhgdlrnfirnethnptvkdligfglqvakgmkflaskkfvhrdlaarncmlde
kftvkvadfglardmlpvkwtaleslqtqkfttksdvwsfgvllwelmtrgappypdvnt
fditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehy
vhvnaty

SCOPe Domain Coordinates for d5hora_:

Click to download the PDB-style file with coordinates for d5hora_.
(The format of our PDB-style files is described here.)

Timeline for d5hora_:

  • d5hora_ appears in periodic updates to SCOPe 2.06 starting on 2016-11-24