Lineage for d5kosb_ (5kos B:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2058814Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2058815Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2060177Family b.50.1.2: Pepsin-like [50646] (11 protein domains)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 2060651Protein Chymosin (synonym: renin) [50667] (3 species)
  7. 2060659Species Human (Homo sapiens) [TaxId:9606] [50669] (72 PDB entries)
  8. 2282990Domain d5kosb_: 5kos B: [326291]
    automated match to d1hrna_
    complexed with 6vs, dms, nag, peg

Details for d5kosb_

PDB Entry: 5kos (more details), 2.41 Å

PDB Description: discovery of tak-272: a novel, potent and orally active renin in- hibitor
PDB Compounds: (B:) renin

SCOPe Domain Sequences for d5kosb_:

Sequence, based on SEQRES records: (download)

>d5kosb_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdp
qhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklm
ealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaiham
dippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records): (download)

>d5kosb_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdslggqivlggsdpqhyeg
nfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealga
kkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippp
tgptwalgatfirkfytefdrrnnrigfalar

SCOPe Domain Coordinates for d5kosb_:

Click to download the PDB-style file with coordinates for d5kosb_.
(The format of our PDB-style files is described here.)

Timeline for d5kosb_:

  • d5kosb_ appears in periodic updates to SCOPe 2.06 starting on 2016-11-17