SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5knja_ (5knj A:)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2199100Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2199101Protein automated matches [190417] (25 species)
    not a true protein
  7. 2199241Species Human (Homo sapiens) [TaxId:9606] [187294] (768 PDB entries)
  8. 2282978Domain d5knja_: 5knj A: [326279]
    automated match to d4m67a_
    complexed with 6ux

Details for d5knja_

PDB Entry: 5knj (more details), 2.88 Å

PDB Description: pseudokinase domain of mlkl bound to compound 1.
PDB Compounds: (A:) mixed lineage kinase domain-like protein

SCOPe Domain Sequences for d5knja_:

Sequence, based on SEQRES records: (download)

>d5knja_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ikeikkeqlsgspwillrenevstlykgeyhrapvaikvfkklqagsiaivrqtfnkeik
tmkkfespnilrifgicidetvtppqfsivmeycelgtlrelldrekdltlgkrmvlvlg
aarglyrlhhseapelhgkirssnflvtqgyqvklagfelrktqtsmslgttraatdrvk
staylspqeledvfyqydvkseiysfgivlweiatgdipfqgcnsekirklvavkrqqep
lgedcpselreiidecrahdpsvrpsvdeilkklst

Sequence, based on observed residues (ATOM records): (download)

>d5knja_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ikeikkeqlsgspwillrenevstlykgeyhrapvaikvfkkaivrqtfnkeiktmkkfe
spnilrifgicidetvtppqfsivmeycelgtlrelldrekdltlgkrmvlvlgaargly
rlhhseapelhgkirssnflvtqgyqvklagfdrvkstaylspqeledvfyqydvkseiy
sfgivlweiatgdipfqgcnsekirklvavkrqqeplgedcpselreiidecrahdpsvr
psvdeilkklst

SCOPe Domain Coordinates for d5knja_:

Click to download the PDB-style file with coordinates for d5knja_.
(The format of our PDB-style files is described here.)

Timeline for d5knja_:

  • d5knja_ appears in periodic updates to SCOPe 2.06 starting on 2016-11-17