SCOPe 2.06: Domain d5toza_: 5toz A:

Lineage for d5toza_ (5toz A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (25 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (882 PDB entries)

8. Domain d5toza_: 5toz A: [326098]
   automated match to d4e4ma_
   complexed with 7h4, so4

Details for d5toza_

PDB Entry: 5toz, 1.98 Å

PDB Description: jak3 with covalent inhibitor pf-06651600

PDB Compounds: (A:) Tyrosine-protein kinase JAK3

SCOPe Domain Sequences for d5toza_:

Sequence, based on SEQRES records:

>d5toza_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqi
lkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssqic
kgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwy
apeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgcerdvpalsrllell
eegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlws

Sequence, based on observed residues (ATOM records):

>d5toza_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqi
lkalhsdfivkyrgvsygslrlvmeylpsgclrdflqrhrarldasrlllyssqickgme
ylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwyapes
lsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmdvpalsrllelleegqrlpa
ppacpaevhelmklcwapspqdrpsfsalgpqldmlws

Timeline for d5toza_:

• d5toza_ is new in SCOPe 2.06-stable
  
• d5toza_ appears in SCOPe 2.07
  
• d5toza_ appears in the current release, SCOPe 2.08