SCOPe 2.08: Domain d5ia0c_: 5ia0 C:

Lineage for d5ia0c_ (5ia0 C:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d5ia0c_: 5ia0 C: [325395]
   automated match to d2jiub_
   complexed with a5b, edo

Details for d5ia0c_

PDB Entry: 5ia0, 1.95 Å

PDB Description: crystal structure of ephrin a2 (epha2) receptor protein kinase with alisertib (mln8237)

PDB Compounds: (C:) Ephrin type-A receptor 2

SCOPe Domain Sequences for d5ia0c_:

Sequence, based on SEQRES records:

>d5ia0c_ d.144.1.7 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
avlkftteihpscvtrqkvigagefgevykgmlktssgkkevpvaiktlkagytekqrvd
flgeagimgqfshhniirlegviskykpmmiiteymengaldkflrekdgefsvlqlvgm
lrgiaagmkylanmnyvhrdlaarnilvnsnlvckvsdfglsrvleddpeatyttsggki
pirwtapeaisyrkftsasdvwsfgivmwevmtygerpywelsnhevmkaindgfrlptp
mdcpsaiyqlmmqcwqqerarrpkfadivsildklirapdslktladfdpr

Sequence, based on observed residues (ATOM records):

>d5ia0c_ d.144.1.7 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
avlkftteihpscvtrqkvigagefgevykgmlktgkkevpvaiktlkatekqrvdflge
agimgqfshhniirlegviskykpmmiiteymengaldkflrekdgefsvlqlvgmlrgi
aagmkylanmnyvhrdlaarnilvnsnlvckvsdfglspirwtapeaisyrkftsasdvw
sfgivmwevmtygerpywelsnhevmkaindgfrlptpmdcpsaiyqlmmqcwqqerarr
pkfadivsildklirapdslktladfdpr

Timeline for d5ia0c_:

• d5ia0c_ first appeared in SCOPe 2.06
  
• d5ia0c_ appears in SCOPe 2.07