SCOPe 2.08: Domain d1a1va2: 1a1v A:326-624

Lineage for d1a1va2 (1a1v A:326-624)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.14: RNA helicase [52724] (7 proteins)
   duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension

6. Protein HCV helicase domain, C-terminal domain [418963] (1 species)

7. Species Human hepatitis C virus (HCV), different isolates [TaxId:11103] [419425] (15 PDB entries)

8. Domain d1a1va2: 1a1v A:326-624 [32468]
   Other proteins in same PDB: d1a1va1
   protein/DNA complex; protein/RNA complex; complexed with so4
   has additional subdomain(s) that are not in the common domain

Details for d1a1va2

PDB Entry: 1a1v, 2.2 Å

PDB Description: hepatitis c virus ns3 helicase domain complexed with single stranded sdna

PDB Compounds: (A:) protein (ns3 protein)

SCOPe Domain Sequences for d1a1va2:

Sequence, based on SEQRES records:

>d1a1va2 c.37.1.14 (A:326-624) HCV helicase domain, C-terminal domain {Human hepatitis C virus (HCV), different isolates [TaxId: 11103]}
pgsvtvphpnieevalsttgeipfygkaiplevikggrhlifchskkkcdelaaklvalg
inavayyrgldvsviptsgdvvvvatdalmtgftgdfdsvidcntcvtqtvdfsldptft
ietttlpqdavsrtqrrgrtgrgkpgiyrfvapgerpsgmfdssvlcecydagcawyelt
paettvrlraymntpglpvcqdhlefwegvftglthidahflsqtkqsgenfpylvayqa
tvcaraqapppswdqmwkclirlkptlhgptpllyrlgavqnevtlthpitkyimtcms

Sequence, based on observed residues (ATOM records):

>d1a1va2 c.37.1.14 (A:326-624) HCV helicase domain, C-terminal domain {Human hepatitis C virus (HCV), different isolates [TaxId: 11103]}
pgsvtvphpnieevalsttgeipfygkaiplevikggrhlifchskkkcdelaaklvalg
inavayyrgldvsviptsgdvvvvatdalftgdfdsvidcntcvtqtvdfsldptftiet
ttlpqdavsrtqrrgrtgrgkpgiyrfvapgerpsgmfdssvlcecydagcawyeltpae
ttvrlraymntpglpvcqdhlefwegvftglthidahflsqtkqsgenfpylvayqatvc
araqapppswdqmwkclirlkptlhgptpllyrlgavqnevtlthpitkyimtcms

Timeline for d1a1va2:

• d1a1va2 first appeared (with stable ids) in SCOP 1.55
  
• d1a1va2 appears in SCOPe 2.07