SCOPe 2.06: Domain d5kyaf1: 5kya F:297-528

Lineage for d5kyaf1 (5kya F:297-528)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein automated matches [190059] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187214] (173 PDB entries)

8. Domain d5kyaf1: 5kya F:297-528 [323111]
   Other proteins in same PDB: d5kyab2, d5kyaf2
   automated match to d4j5xc_
   complexed with 6y4

Details for d5kyaf1

PDB Entry: 5kya, 2.6 Å

PDB Description: brain penetrant liver x receptor (lxr) modulators based on a 2,4,5,6- tetrahydropyrrolo[3,4-c]pyrazole core

PDB Compounds: (F:) Retinoic acid receptor RXR-beta

SCOPe Domain Sequences for d5kyaf1:

Sequence, based on SEQRES records:

>d5kyaf1 a.123.1.1 (F:297-528) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eempvdrileaelaveqksdqgvegpggtggsgsspndpvtnicqaadkqlftlvewakr
iphfsslplddqvillragwnelliasfshrsidvrdgillatglhvhrnsahsagvgai
fdrvltelvskmrdmrmdktelgclraiilfnpdakglsnpsevevlrekvyasletyck
qkypeqqgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemlea

Sequence, based on observed residues (ATOM records):

>d5kyaf1 a.123.1.1 (F:297-528) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eempvdrileaelavepvtnicqaadkqlftlvewakriphfsslplddqvillragwne
lliasfshrsidvrdgillatglhvhrnsahsagvgaifdrvltelvskmrdmrmdktel
gclraiilfnpdakglsnpsevevlrekvyasletyckqkypeqqgrfaklllrlpalrs
iglkclehlfffkligdtflmemlea

Timeline for d5kyaf1:

• d5kyaf1 is new in SCOPe 2.06-stable
  
• d5kyaf1 appears in SCOPe 2.07
  
• d5kyaf1 appears in the current release, SCOPe 2.08