SCOPe 2.08: Domain d5jt2b1: 5jt2 B:448-719

Lineage for d5jt2b1 (5jt2 B:448-719)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d5jt2b1: 5jt2 B:448-719 [322869]
   Other proteins in same PDB: d5jt2a2, d5jt2b2, d5jt2c2, d5jt2d2
   automated match to d2dq7x_
   complexed with 6nc, ben

Details for d5jt2b1

PDB Entry: 5jt2, 2.7 Å

PDB Description: brafv600e kinase domain in complex with chemically linked vemurafenib inhibitor vem-bisamide

PDB Compounds: (B:) Serine/threonine-protein kinase B-raf

SCOPe Domain Sequences for d5jt2b1:

Sequence, based on SEQRES records:

>d5jt2b1 d.144.1.0 (B:448-719) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdyl
haksiihrdlksnniflhedntvkigdfglateksrwsgshqfeqlsgsilwmapevirm
qdsnpysfqsdvyafgivlyelmtgqlpysninnrdqiiemvgrgslspdlskvrsncpk
rmkrlmaeclkkkrderpsfprilaeieelar

Sequence, based on observed residues (ATOM records):

>d5jt2b1 d.144.1.0 (B:448-719) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlntpqqlqafknevgvlrktrhv
nillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdylhaks
iihrdlksnniflhedntvkigdfglatsilwmapevirmsnpysfqsdvyafgivlyel
mtgqlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrderpsfpr
ilaeieelar

Timeline for d5jt2b1:

• d5jt2b1 first appeared in SCOPe 2.06
  
• d5jt2b1 appears in SCOPe 2.07