SCOPe 2.08: Domain d5lr6c_: 5lr6 C:

Lineage for d5lr6c_ (5lr6 C:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families)

5. Family c.66.1.1: COMT-like [53336] (4 proteins)

6. Protein Catechol O-methyltransferase, COMT [53337] (2 species)

7. Species Norway rat (Rattus norvegicus) [TaxId:10116] [53338] (87 PDB entries)

8. Domain d5lr6c_: 5lr6 C: [322012]
   automated match to d4pyna_
   complexed with 731, cl, nhe

Details for d5lr6c_

PDB Entry: 5lr6, 2.3 Å

PDB Description: crystal structure of comt in complex with [3-(2,4-dimethyl-1,3- thiazol-5-yl)-1h-pyrazol-5-yl]-(4-phenylpiperazin-1-yl)methanone

PDB Compounds: (C:) Catechol O-methyltransferase

SCOPe Domain Sequences for d5lr6c_:

Sequence, based on SEQRES records:

>d5lr6c_ c.66.1.1 (C:) Catechol O-methyltransferase, COMT {Norway rat (Rattus norvegicus) [TaxId: 10116]}
dtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspslv
lelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqdl
ipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdflay
vrgsssfecthyssyleymkvvdglekaiyqgpss

Sequence, based on observed residues (ATOM records):

>d5lr6c_ c.66.1.1 (C:) Catechol O-methyltransferase, COMT {Norway rat (Rattus norvegicus) [TaxId: 10116]}
dtkeqrilryvqqnakpgdpqsvleaidtyctqkewanvgdakgqimdavireyspslvl
elgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqdli
pqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdflayv
rgsssfecthyssyleymkvvdglekaiyqgpss

Timeline for d5lr6c_:

• d5lr6c_ first appeared in SCOPe 2.06
  
• d5lr6c_ appears in SCOPe 2.07