SCOPe 2.07: Domain d1efha1: 1efh A:4-285

Lineage for d1efha1 (1efh A:4-285)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.5: PAPS sulfotransferase [52575] (15 proteins)
   Pfam PF00685
   similar to the nucleotide/nucleoside kinases but transfer sulphate group

6. Protein Hydroxysteroid sulfotransferase sult2a1 [52578] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52579] (6 PDB entries)

8. Domain d1efha1: 1efh A:4-285 [31948]
   Other proteins in same PDB: d1efha2, d1efhb2
   complexed with a3p

Details for d1efha1

PDB Entry: 1efh, 2.4 Å

PDB Description: crystal structure of the human hydroxysteroid sulfotransferase in the presence of pap

PDB Compounds: (A:) hydroxysteroid sulfotransferase

SCOPe Domain Sequences for d1efha1:

Sequence, based on SEQRES records:

>d1efha1 c.37.1.5 (A:4-285) Hydroxysteroid sulfotransferase sult2a1 {Human (Homo sapiens) [TaxId: 9606]}
dflwfegiafptmgfrsetlrkvrdefvirdedviiltypksgtnwlaeilclmhskgda
kwiqsvpiwerspwveseigytalsetesprlfsshlpiqlfpksffsskakviylmrnp
rdvlvsgyffwknmkfikkpksweeyfewfcqgtvlygswfdhihgwmpmreeknfllls
yeelkqdtgrtiekicqflgktlepeelnlilknssfqsmkenkmsnysllsvdyvvdka
qllrkgvsgdwknhftvaqaedfdklfqekmadlprklaaal

Sequence, based on observed residues (ATOM records):

>d1efha1 c.37.1.5 (A:4-285) Hydroxysteroid sulfotransferase sult2a1 {Human (Homo sapiens) [TaxId: 9606]}
dflwfegiafptmgfrsetlrkvrdefvirdedviiltypksgtnwlaeilclmhskgda
kwiqsvpiwerspwveseigytalsetesprlfsshlpiqlfpksffsskakviylmrnp
rdvlvsgyffwknmkfikkpksweeyfewfcqgtvlygswfdhihgwmpmreeknfllls
yeelkqdtgrtiekicqflgktlepeelnlilknssfqsmkenkmsnysllsvdyvvdql
lrkgvsgdwknhftvaqaedfdklfqekmadlprklaaal

Timeline for d1efha1:

• d1efha1 first appeared (with stable ids) in SCOP 1.55, called d1efha_
  
• d1efha1 appears in SCOPe 2.06
  
• d1efha1 appears in the current release, SCOPe 2.08