SCOPe 2.08: Domain d5hfab_: 5hfa B:

Lineage for d5hfab_ (5hfa B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (43 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.1: Acetylcholinesterase-like [53475] (6 proteins)
   automatically mapped to Pfam PF00135

6. Protein Acetylcholinesterase [53476] (6 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53480] (52 PDB entries)

8. Domain d5hfab_: 5hfa B: [318825]
   automated match to d2xupa_
   complexed with dep, edo, fp1, nag, no3

Details for d5hfab_

PDB Entry: 5hfa, 2.2 Å

PDB Description: crystal structure of human acetylcholinesterase in complex with paraoxon and 2-pam

PDB Compounds: (B:) acetylcholinesterase

SCOPe Domain Sequences for d5hfab_:

Sequence, based on SEQRES records:

>d5hfab_ c.69.1.1 (B:) Acetylcholinesterase {Human (Homo sapiens) [TaxId: 9606]}
redaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvda
ttfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiyggg
fysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqw
vqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmg
earrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpv
vdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflag
vrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqg
arvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywan
fartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsa

Sequence, based on observed residues (ATOM records):

>d5hfab_ c.69.1.1 (B:) Acetylcholinesterase {Human (Homo sapiens) [TaxId: 9606]}
redaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvda
ttfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiyggg
fysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqw
vqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmg
earrratqlahlvgcpptggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvd
gdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvr
vgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgar
vyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfa
rtgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsa

Timeline for d5hfab_:

• d5hfab_ first appeared in SCOPe 2.06
  
• d5hfab_ appears in SCOPe 2.07