SCOPe 2.08: Domain d4zsed_: 4zse D:

Lineage for d4zsed_ (4zse D:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (133 PDB entries)
   Uniprot P00533 702-1018

8. Domain d4zsed_: 4zse D: [318635]
   automated match to d3ikaa_
   complexed with anp, edo, mg

Details for d4zsed_

PDB Entry: 4zse, 1.97 Å

PDB Description: crystal structure of egfr 696-1022 t790m/v948r, crystal form ii

PDB Compounds: (D:) Epidermal growth factor receptor

SCOPe Domain Sequences for d4zsed_:

Sequence, based on SEQRES records:

>d4zsed_ d.144.1.7 (D:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
qallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeil
deayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvq
iakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikw
malesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppict
idvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyra
lmdeedmddvvdade

Sequence, based on observed residues (ATOM records):

>d4zsed_ d.144.1.7 (D:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
qallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelrespkankeilde
ayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgvpikwmalesilhriythq
sdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmid
adsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeevvdade

Timeline for d4zsed_:

• d4zsed_ first appeared in SCOPe 2.06
  
• d4zsed_ appears in SCOPe 2.07